Targeting senescence
نویسندگان
چکیده
منابع مشابه
Targeting Cancer by Inducing Senescence
The concept of senescence as a barrier to tumorigenesis, either by natural replicative limits or as stress-induced senescence deserves a critical evaluation of the benefits that can be achieved for cancer diagnosis and therapy. It is accepted that neoplastic cells can be forced to undergo senescence by genetic manipulations and by epigenetic factors, including anticancer drugs, radiation and di...
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OBJECTIVES Endothelial progenitor cells (EPCs) play an important role in postnatal neovascularization. The number and function of EPCs declines as part of aging-associated senescence, thereby potentially contributing to vascular pathologies. Here, we investigated the significance and molecular mechanisms of microRNA-22 (miR-22) governing EPC senescence. METHODS EPCs were isolated from human c...
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The CD20-targeting monoclonal antibody rituximab is an established component of immunochemotherapeutic regimens against B-cell lymphomas, where its coadministration with conventional anticancer agents has significantly improved long-term outcome. However, the cellular mechanisms by which rituximab exerts its antilymphoma activity are only partially understood. We show here that rituximab induce...
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Cellular senescence occurs as a response to extracellular and intracellular stresses and contributes to aging and age-related pathologies. Emerging evidence suggests that cellular senescence also acts as a potent tumor suppression mechanism that prevents the oncogenic transformation of primary human cells. Recent reports have indicated that miRNAsact as key modulators of cellular senescence by ...
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ژورنال
عنوان ژورنال: Nature Reviews Neuroscience
سال: 2019
ISSN: 1471-003X,1471-0048
DOI: 10.1038/s41583-019-0173-x